I tried tuning using vacuum once, only because I hadn't tried it before and bought a gauge.
I would say that my experiences were mixed. I normally set using a strobe. I found that tuning using the gauge meant i had to make some changes. The upshot was an hour of tail chasing. It was an interesting exercise, but i pretty much ended up setting the car up by ear in the end. Vacuum settings according to the BBB are fine, but the settings were for cars that were new/ish. For one to really be able to nail tuning using vacuum readings, it may help to ensure all other factors are addressed first, like linkage, butterfly, etc. Joe's excellent tour takes care of that.
I think my engine was a bit worn to be able to make much use book values, but as i said, an interesting afternoon.
If anyone wants to buy a vacuum gauge, i know of one for sale!!