Hello Bianchito,
Actually, I did some experimenting with this switch years ago. However the passages in the crankshaft, bearings and connecting rods are different. The cranshafts are different in other ways also. You would have to replace the crankshaft and the connecting rods as a unit using the correct bearings.
My experience has never shown me that there was a real weakness in the 250 enine. I do believe that when Mercedes designs a new engine, that they try to "improve" and incorporate latest design features in the newer engine. So as far as being "defective or weak", I probably do not agree. As far as latter engines being improved, possibly!
I know lots of high mileage 250SLs. The secret to longevity is good maintenance, and good storage. The earlier engines 230, 250 were a lot more foregiving as far as oveheating...more space between cylinders. However any of the engines can be ruined from severely overheating.
Joe Alexander
Blacklick, Ohio