I used to experience stumble/hesitation/rough running when the engine was cold (only the first 30 or so seconds though, and the cold start systems checked out ok then), and at high RPM (>4500) when the engine was at operating temp - it was finally eliminated when the engine head was reconditioned. This was necessitated when the head gasket developed a leak.
My car never 'pinks' and, despite the engine having rather poor compression, still pulls pretty strong.