I did this test the other day. With the fuel gauge on the 'E' mark, where in my 20+ years of ownership I always decided better fill up but then was always wondering why I could only fit about 60 liters in rather than towards the 80 that a 280 SL is supposed to be able to take, I decided to siphon out all the remaining fuel in the tank. Indeed another 20 or so liters came out and, for the first time in my ownership history, the little warning light came on!
So I finally settled that the fuel gauge is essentially way too pessimistic and when the needle is that low, there's still around 20 liters available and I only need worry when the light comes on.
Of course, BobH's method is much, much easier!
Carrying a little 5 liter reserve tank in the boot can be a good idea, just in case that next station is too far for comfort.