Those bolts and nuts working themselves loose can be the result of the manifold/downpipe not being a tension-fit. The flange is supposed to force the down pipe into the manifold and the joint should be under tension at all times; this prevents the bolts/nuts from coming loose.
I had this problem for a couple of years, when, no matter what I tried (lock washers, new bolts, new nuts), the nuts would always work themselves loose. Then I replaced my downpipes and the problem went away.
Cees ("Case") Klumper in Amsterdam
'69 white 280 SL automatic