in the 280SL's - m130e motor it is not unusual for problems to show up on just the #5 cylinder (or the #4) before the other cylinders, the 2.8 litre motor was designed ca. 1955 as a 2.2 litre motor and over the years was bored and stroked up to 2.8 litres,
this left the cylinder walls very thin between the #4 & 5 cylinders and causes a hot spot in the back of the block. This in time will manifest itself as wear of the bore of these two cylinders before the others wear, higher temperatures in the cylinder head in this area, causing premature wear of valve guide, seals and / or spark plug fowling.
I'd suggest just changing the #5 plug and monitor how long it lasts before it fowls again, and if it fowls frequently check and replace the valve stem seals on the #5 cylinder.
Al