Hi Kopie,
The wiring diagrams for the 280SL show a dotted line coming from fuse 3. It goes nowhere. The wiring diagram for the 280SE indicates the only circuit involved with fuse three is the kick down switch and solenoid valve for the auto trans.
When the fuse blows are you actively using the kick down switch? In other words are you slamming the accelerator pedal down to engage the kick down switch to force the transmission into a lower gear? If not, I would suggest a failure in the kick down switch where it is shorted to ground. This would indicate a short in the blark/red wire from fuse 3 to the kick down switch. Should be easy to trace, everything is under the dask, the switch is located behind the accelerator pedal.
Its odd though. The kick down switch is normally open. When activated it provides 12 v to the solenoid which in turn asks the transmission for a lower gear. If the fuse blows there is no power to ask the trans for a lower gear. You indicate that when the fuse blows the trans clunks into a lower gear. This is not possible according to the 280SEwiring diagram.
I'd start by examining the kick down switch. Take it out, apart if you can and clean it. then inspect the wiring for shorts.
Good luck