I have had a vibration in my 250 SL at about 55-60 mph pretty much since I have had the car (almost 14 years now). I finally decided to attack the issue. It also turned out that the drive shaft was not the correct one for the year/VIN. My mechanic had the rear part, a new unit, he sold me. I was able to get the front shaft from a friend who has various and sundry parts. I had the front shaft shortened to fit, and then the entire unit balanced and marked. A friend of mine and I put the new shaft in place a week and a half ago, but the vibrations are still there, in a different speed (on at about 65-70 and another smaller at ~40), but still noticeable, mostly in the rear view mirror. The only real trouble we had was getting the center guide mount in place.
There are two channels in the body that hold an adjustable nut that the center guide bolts to. One of the channels was messed up and it took us hours to finally get the guide bolted up. The guide bearing does not look fully centered, but do not really have a good reference on this. Could that be a part of the problem??
I also do need to get new tires, the old Cokers are pretty well past their time. Next up is a purchase of new white walls.
In reading through the threads, tires do play a part, and since I know these need to be replaced, the detective work will continue.