Start with the ignition...though our fuel systems are "injected" I always remember the quip from an old service manual I once had for an MG, where they stated "Carburettor is a French word meaning 'It's the electrical system, stupid!' "
At 4,000 RPM your moving parts are screaming along and you are asking a lot of the distributor, points, plugs, wires, etc. Might be something as simple as dirty wires causing electrical breakdown...been there and done that on other cars...