I am not an expert by any means, but I struggled quite a lot with engine misfiring, firing in manifold and hestitating, fixed that, now I am into differing colours of the spark plugs.
What I found useful was when I applied some system to the approach:
1. The most basic things first - ignition leads and sparks
2. Valves
2. Basic settings first - dwell, ignition timing (here I went finally for 123 with settings advised on the Forum of 8BTDC everything connected @idle, 38BTDC everything connected @3000rpm)
3. Linkage tour
4. The mixture composition - assessment of overall mixture composition across speeds - just by the spark plug colour, then on idle based on split linkage test before I got Gunson (does not work vice-versa, you have to have mixture across rpm range more or less ok before moving on to idle adjustment)
I am not sure, but if the colour of this one spark plug is different than the colour of others and the others have the colour similar to those two you show on the picture, it may as well be that it is just that cylinder and not overall adjustment is the reason for misfires. And this can be spark plug, ignition lead or leaking injector - as the simplest culprits. Just by the colour of the two spark plugs - I would have thought the settings are ok, you misfire because of that one cylinder, but that is just my thought.
Do not take me literally as I am not qualified enough, but trying to plan some systematic approach will definitely help.