Hi Peter, I have a 250 with a 69 280 motor, I've owned since 1971. I have adjusted the pump on the car with excellent, maybe surprising, results. I started many years ago using the manual prescribed "tail sniffer" to measure CO2. I didn't have much success. Repeatability and accuracy were poor. I got closer with a narrow band O2 meter with sensor in a tail pipe. Finally I replaced it with a wide band meter and sensor. It is accurate and repeats. (and a vacuum meter visible as you drive.)
The big problem is the 280 pumps oil level is above the big access nut. You loose 1/2 quart of oil each time you open the pump to adjust the Lower partial and upper partial screws. And of course, they effect each other as all 4 springs press on the same two counter balance weights. Hopefully you have a reasonable bench adjustment to start with. You also have the full load rack screw that is above the oil level. But it also moves the governor settings richer or leaner.
Yes they are interactive and take patience, comprehension, and many many circuits over the same "test track." A few of my neighbors noticed and asked why I was driving around and around putting my breaks on for no seeable reason. I live on a mile round circle with 2 hills that help releave the brakes as I try to maintain the vacuum at 1500 and 3000 RPM.
I found it best to adjust the cold start and idle shims 1st. Then the governor 4 screws. Then check the shims again. Once you get all that for highest power (which for my car was a bit rich), You can now use the rack for wide open throttle, which again can move the governor band rich or lean, but now you are really close and readjusting the governor and shims will require small adjustment. And I found if I wanted highest performance or a bit of gas economy, I can just adjust the rack a few clicks without dumping 1/2 quart of oil.
My pump had been setup very rich causing an extensive iterative process and many quarts of oil, but once I found the sweet spot, the performance felt 15 to 20% improved.
I also pressure tested my injectors and found at about 100K miles the injectors were fine!
The result is a big smile on my face as I'm driving fun roads.