In general, however the old panel is welded, you want to weld the new one. (spot-welds, continous.....)
Use the new panel as a template to insure you are not cutting too much. Use the trunk lid, bumper holes and
side fender gaps to verify alignment before welding. Not sure where your replacement panel came from, but the MB OEM panels, when available, have imo a better fit than the aftermarket ones.