If I were you I would check the proper operation of all of the components of the ignition, including the vacuum governor (check the timing at the different listed RPM's with and without vacuum attached). But I think that where you set the timing in absolute terms also has a lot to do with this. Finally, I recall reading that a leak at the exhaust manifold somewhere can also cause popping (now is popping the same as backfiring?).
Cees ("Case") Klumper in Amsterdam
'69 white 280 SL automatic